In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites.
نویسندگان
چکیده
wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). One of these derivatives inhibited gliding motility of Plasmodium berghei ANKA infectious sporozoites with nanomolar affinity and blocked invasion into hepatocytes but did not affect intrahepatocytic replication. Hence, wALADin1 benzimidazoles are tools to study gliding motility and potential antiplasmodial drug candidates.
منابع مشابه
In vitro activity of wALADin - benzimidazoles 1 against different life - cycle stages of Plasmodium 2 parasites 3 4
16 wALADin1-benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from 17 Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives 18 killed blood-stage Plasmodium falciparum in vitro (IC50 = 39, 7.7, and 12.8 μM, 19 respectively). One of these derivatives inhibited gliding motility of Plasmodium berghei 20 AAC Accepts, published online ahe...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 59 1 شماره
صفحات -
تاریخ انتشار 2015